![]() ![]() ![]() ![]() These results suggest that intranasal administration bypasses the blood–brain barrier, delivering oxytocin to specific brain regions, such as the striatum, where oxytocin acts to impact motivated behaviors. Labeled oxytocin is quantified after intranasal (not intravenous) administration in brain regions (orbitofrontal cortex, striatum, brainstem, and thalamus) that lie in the trajectories of the olfactory and trigeminal nerves. In this nonhuman primate study, we administer deuterated oxytocin intranasally and intravenously to rhesus macaques and measure, with mass spectrometry, concentrations of labeled (exogenously administered) and endogenous oxytocin in 12 brain regions two hours after oxytocin administration. To date, the brain tissue penetrance of intranasal oxytocin has not been demonstrated. Its therapeutic effect may depend on its ability to enter the brain and bind to the oxytocin receptor. Oxytocin may have promise as a treatment for neuropsychiatric disorders. ![]()
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